Trifluoroborates are new classes of air-stable boronic acid derivatives that can be easily prepared and purified. Trifluoroborates offer a unique alternative to most boronic acids, esters and organoboranes for use in Suzuki-Miyaura and other transition-metal-catalyzed cross-coupling reactions, as described by Dr. Gary Molander.
The incompatibility of B-C bond with several oxidants limits the possibilities to further transformations of organoboron derivatives. Taking advantage of strong B-F bonds, the use of trifluoroborates may be viewed as a way to protect boron’s vacant orbital from an electrophilic reaction.
Advantages of trifluoroborates
Main benefits of the use of trifluoroborates in Suzuki-Miyaura cross-couplings