Contents :  Happy New Year |  Focus on Piperazinones  |  Zoom on Boronic Heterocycles  |  Special offer

BOROCHEM WISHES YOU A HAPPY, HEALTHY AND PROSPEROUS NEW YEAR!

We have greatly appreciated working with you in 2009 and thank you for your confidence. We hope that 2010 will bring you health, happiness and success, and look forward to collaborating with you again this year.

2010 also marks BoroChem's 5th anniversary with special events to come! We kick off the New Year with a fresh Newsletter. This newsletter will now be bimonthly, and will feature a Zoom on a selection of newly released products as well as a Focus on a chemical, biochemical or biological application using boron chemistry. These applications can all be customized to fit your specific needs, whether they are unnatural amino-acids or amino-alcohols, rare phenols, hydroxylated heterocycles, diversily functionalised biphenyls or biheteroaromatics among others. We will continue to expand our catalogue with innovative and high-quality building blocks in 2010, and will, in between two newsletters, keep you up to date with our special offers. Enjoy this 11th newsletter!

FOCUS ON THE FORMATION OF PIPERAZINONES
The design and synthesis of peptidomimetics continues to be an area of intense interest in medicinal chemistry. Piperazinones (2-oxopiperazines) are interesting examples that mimic a given peptide conformation. Using organoborons in a Boron Mannich type Reaction (BMR) can lead to a wide diversity of such piperazinones very easily.





Examples of good partners for BMR, included in our 2010 catalogue, comprise the following compounds:

       

       

For more details on the design and synthesis of peptidomimetics, see Petasis, N. A.; Patel, Z. D., Tet. Lett. 41 (2000) 9607-9611.

ZOOM ON NEW HETEROCYCLIC BORONIC ACIDS AND ESTERS
The following small nitrogen-containing 5-membered heterocycles have recently been released. For more information, click on the compounds.

      

We are curently working on new 5-membered heterocycles with different functional groups, that will be released throughout the year.



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SPECIAL OFFER ON DISCOVERY KIT
A new discovery kit is born! Take advantage of this month's special offer on the following indole, azaindole, indazole and quinoline:

       

Get this discovery kit DK2-100112 (4 x 250 mg) for only € 250 (360 USD) !

Please mention discount code 10NL11 with your order.

This offer is valid until 28th February 2010. This e-mail address is being protected from spambots. You need JavaScript enabled to view it