Where Trifluoromethyl and Boron meet, promising molecules lead!
Newsletter N° 22 - July 2012aThe presence of trifluoromethyl groups in organic molecules has a profound effect on their physical and chemical properties. Trifluoromethyl-substituted compounds often display improved metabolic stability, better receptor binding selectivity, higher lipophilicity, increased bioavailability, or stronger dipole moments than non-fluorinated analogues.1
New methods to introduce trifluoromethyl groups into organic substrates are thus of constant high interest for the synthesis of pharmaceuticals, agrochemicals, and functional materials.2 Exemples of approved trifluoromethylated drugs include Eli Lilly’s fluoxetine antidepressant (Prozac, Sarafene)3 and Bayer’s trifloxystrobin fungicide (Flint)4. Exemples of commercially available trifluoromethylarenes in functional materials include liquid crystal compound ZLI-2857 used in LCD screens.5
Approved trifluoromethylated molecules
BoroChem proposes one of the largest selections of trifluoromethylated heteroaromatics on catalogue. Our collection of close to 300 trifluoromethylated molecules has recently been expanded with the following trifluoromethylated compounds, which can be cross-coupled to your desired molecules.
You can also search our online database of boronic and halogenated heterocycles for detailed product information.
1. S. Purser, P.R. Moore, S. Swallow, V. Gouverneur, Chem. Soc. Rev., 2008, 37, 320−330.
2. P. Kirsch, M. Bremer, Angew. Chem., 2000, 112, 4384-4405, Angew. Chem. Int. Ed. 2000, 39, 4216-4235.
3. D.T. Wong, K.W. Perry, F.P. Bymaster, Nat. Rev. Drug Discovery, 2005, 4, 764-774.
4. P. Margot, F. Huggenberger, J. Amrein, B. Weiss, BCPC Conf.-Pests. Dis., 1998, 2, 375-385.
5. V. Reiffenrath, J. Krause, H.J. Plach, G. Weber, Liq. Cryst., 1989, 5, 159-170.