Nature loves nitrogen heterocycles, so does BoroChem!

Newsletter N° 21 - April 2012

Nitrogen heterocycles are central structures for the chemistry of life.¹ This is particularly evident in the heteroaromatic single ring pyrimidines, pyridines, thiazoles, imidazoles, ... that are essential for both structural and reactivity determinants of many new drugs.

A survey of drugs approved in recent times or currently in clinical trials turns up many variants of five- and six-membered rings, often fused as bicyclic scaffolds, with multiple nitrogen atoms. As noted in the structures below, chemists can utilize the same heterocyclic nitrogen building blocks as found in Nature while exploiting unnatural ones to bolster their pipelines.



Some approved drugs containing nitrogen heterocycles in their synthetic scaffolds

Given their proven interest in medicinal chemistry^{2, 3}, BoroChem has added 450 new thiazoles, indazoles and azaindoles to its catalogue.



This is the first selection of up to 6,000 nitrogen heterocycles that will be added to our catalogue over the upcoming six months!.

This e-mail address is being protected from spambots. You need JavaScript enabled to view it to receive the complete list of nitrogen heterocycles that will be released this year in either SDF or XLS format.

You can also search our online database of boronic and halogenated heterocycles or This e-mail address is being protected from spambots. You need JavaScript enabled to view it for tailor-made new compounds.

BoroChem can help you make your chemistry easier! Please This e-mail address is being protected from spambots. You need JavaScript enabled to view it for any requests.

References
1.  ACS Chem. Biol., 2012, 7, 429−442
2.  Tetrahedron, 2007, 63, 8689–8707
3.  Der Pharma Chemica, 2011, 3, 523-537