Newsletter N° 17 - May 2011
Contents : Suzuki-Miyaura Cross-Coupling in details | BoroChem's collaborative system | BoroChem at Chemspec Europe
Suzuki-Miyaura Cross-Coupling in details
The Suzuki-Miyaura reaction typically involves the cross-coupling of organoboron compounds with organohalides (or their equivalents). The reaction is catalyzed by the tandem Palladium(0)/phosphine complex and requires a base for the transmetalation step. However, with 3 possible organoboron reagents (taken from a boronic acid or ester, or a trifluoroborate salt), 4 organohalides or equivalent (chosen from chlorine, bromine, iodine and triflate derivatives), and a huge choice of catalysts, bases, solvents, mode of heating and reaction time, the experimental conditions pattern is substantial.
Consequently, finding suitable and efficient conditions for a first try is troublesome and the initial combination is rarely optimal. To the best of our knowledge, there is no study that tries to rule on the guidelines of a first cross-coupling, yet the Suzuki-Miyaura reaction is widely used all over the world. Thus, the need for a general tool to begin with is essential and the use of Web 2.0, where everybody can share and communicate, can be helpful.
BoroChem's collaborative system
In order to enable easy sharing and communication, BoroChem just launched its collaborative system tool: a forum dedicated to organoboron derivatives and their applications in the chemical and therapeutic fields.
Access the forum on BoroChem's website
BoroChem at Chemspec EuropeWe look forward to meeting you there!
BoroChem will be exhibiting at the upcoming Chemspec Europe, held in Geneva, Switzerland from June 15 to 16th, stand N26.