Newsletter N° 16 - March 2011
Contents : Potassium trifluoroborates
Focus on potassium trifluoroborates
Once again we will talk about trifluoroborates as there is major news!
Trifluoroborates have been an amazing success but their scale-up pointed out structural anomalies. The BoroChem team was the first to warn you about this problem in our 12th newsletter. The answer to this issue came from the Molander's team who gave us a preview of the following information as part of our Scientific Board.
The article soon be published (1) but results are already available here.
To summarize, aminomethyltrifluoroborates are not free bases, but internal salts (zwitterionic ammoniomethyltrifluoroborates with small amounts of KBr) :
The products keep their amazing possibilities, especially in Suzuki cross-couplings.
Their characteristics remain quite similar and the usefulness of those building blocks has been proven beyond doubts, so you will still find them at unchanged prices in our product list with corrected names, structures, and formulas as follows (other compounds remain unchanged):
As a reminder, do not forget that organoboronated salts are a serious alternative to boronic acids.
(1) Reinvestigation of Aminomethyltrifluoroborates and Their Application in Suzuki-Miyaura Cross-Coupling Reactions, Raushel, J.; Sandrock, DL.; Josyula, KV.; Pakyz, D.; Molander, GA. ; J. Org. Chem, 2011, ASAP